Tara M. Caffrey

Strategies to improve neurite outgrowth from primary neurons ingelatin methacrylate hydrogels polymerized with visible lightexposure inside a microscale 3D model

This study evaluates GelMA hydrogel properties for promoting neurite outgrowth from DRG explants, finding that 3% GelMA with 95% DoF supports the longest neurite extension.

Engineering a Multilayer Microfluidic Airway-On-A-Chip with Tunable GelMA Hydrogel for Physiologically Relevant Aerosol Exposure Studies

This paper develops a microfluidic airway-on-a-chip with GelMA hydrogel for studying smoke-induced airway responses, showing inflammatory and fibrotic effects from TGF-β1 and wood smoke exposure.

Effects of MRI on an Injectable Hydrogel with Magnetically Alignable Microstructures for Oriented Cell Growth

This study examines the effects of MRI on an injectable hydrogel with magnetic microstructures, finding no change in alignment or heat generation under MRI exposure.

Optical Properties of Gelatin Methacrylate and Implications for In Situ Cross-Linking in Spinal Cord Lesions and EngineeredHydrogel Systems

This paper measures the optical properties of GelMA hydrogels and evaluates their cross-linking feasibility in spinal cord injuries using simulations and experiments.

Tau depletion in human neurons mitigates A beta-driven toxicity

This study shows that reducing tau in human neurons decreases A beta toxicity, supporting the role of tau in Alzheimer's disease mechanisms.

A novel post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson's disease GBA-N370S dopamine neurons

This study uses a novel proteomics platform to identify PTM dysregulation in GBA-N370S PD neurons, revealing impaired neuritogenesis and a role for tau.

A human single-cell atlas of the Substantia nigra reveals novel cell-specific pathways associated with the genetic risk of Parkinson's disease and neuropsychiatric disorders.

The paper constructs a single-cell atlas of the Substantia nigra and identifies cell-specific gene expression patterns linked to Parkinson's disease and neuropsychiatric disorders.