Loss of HMGCS2-mediated intestinal stem cell ketogenesis is a metabolic barrier to mucosal healing in Ulcerative colitis
Duncan G. Rutherford, Verity E Cowell, Robert J Whelan, Alexandra J. Cavanagh, Claire E. Adams, Peter D Cartlidge, Phoebe Y Lau, Mairi H. Hodge, Nigel Balfour Jamieson, Claire Kennedy Dietrich, Darren Ruane, Joshua James Rusbuldt, Koichi Hashikawa, Anna Smith, Laura C. Greaves, , Gwo‐Tzer Ho
The paper shows loss of HMGCS2-mediated ketogenesis in intestinal stem cells impairs mucosal healing in Ulcerative colitis and identifies {beta}HB as a potential therapeutic target.
bioRxiv · Aug 25, 2025 · PreprintCell Biology