Koichi Hashikawa

Loss of HMGCS2-mediated intestinal stem cell ketogenesis is a metabolic barrier to mucosal healing in Ulcerative colitis

The paper shows loss of HMGCS2-mediated ketogenesis in intestinal stem cells impairs mucosal healing in Ulcerative colitis and identifies {beta}HB as a potential therapeutic target.

Post-ejaculatory Inhibition of Female Sexual Drive via Heterogeneous Neuronal Ensembles in the Medial Preoptic Area

The paper shows that male ejaculation reduces female sexual motivation by activating specific inhibitory neurons in the medial preoptic area of mice.

Esr1-Dependent Signaling and Transcriptional Maturation in the Medial Preoptic Area of the Hypothalamus Shapes the Development of Mating Behavior during Adolescence

Single cell RNA sequencing reveals how adolescent sex hormones sculpt hypothalamic cell types required for mating behavior.

Opto-seq reveals input-specific immediate early gene induction in ventral tegmental area cell types

The paper uses optogenetic stimulation and single-nucleus RNA sequencing to identify input-specific activation patterns of VTA neuronal subpopulations and their immediate early gene programs.

Opioid-driven disruption of the septal complex reveals a role for neurotensin- expressing neurons in withdrawal

The paper identifies Neurotensin-expressing neurons in the lateral septum as critical for opioid withdrawal by showing their activation and role in regulating withdrawal behaviors.

Pubertal sex hormones control transcriptional trajectories in the medial preoptic area

The paper investigates how pubertal sex hormones regulate transcriptional changes in the medial preoptic area of mice during puberty, revealing sexually dimorphic gene regulatory networks.

Transcriptional and Spatial Resolution of Cell Types in the Mammalian Habenula

The paper identifies and spatially defines transcriptionally distinct neuronal cell types in the mouse habenula and shows their conservation with zebrafish.

Sensory Detection of Aversive and Appetitive Stimuli by CRF neurons

The paper shows that PVN CRF neurons respond rapidly to aversive and appetitive stimuli in mice, suggesting their role in sensory detection and neuroendocrine regulation.