This study profiles the gastrointestinal tract over three months post-stroke in an experimental model, showing structural and microbial changes that persist chronically.

Journal of Cerebral Blood Flow & Metabolism · Jan 17, 2026Peer-reviewedImmunology

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair

Lizi M. Hegarty, Gareth‐Rhys Jones, Adi Biram, Claire E. Adams, Rebecca Gentek, Gwo‐Tzer Ho, Elaine Emmerson, Calum C. Bain

This study identifies three subpopulations of colonic macrophages in mice, showing they persist through inflammation and adapt transcriptionally to aid tissue repair.

Mucosal Immunology · Nov 20, 2025Peer-reviewedImmunology

Loss of HMGCS2-mediated intestinal stem cell ketogenesis is a metabolic barrier to mucosal healing in Ulcerative colitis

Duncan G. Rutherford, Verity E Cowell, Robert J Whelan, Alexandra J. Cavanagh, Claire E. Adams, Peter D Cartlidge, Phoebe Y Lau, Mairi H. Hodge, Nigel Balfour Jamieson, Claire Kennedy Dietrich, Darren Ruane, Joshua James Rusbuldt, Koichi Hashikawa, Anna Smith, Laura C. Greaves, , Gwo‐Tzer Ho

The paper shows loss of HMGCS2-mediated ketogenesis in intestinal stem cells impairs mucosal healing in Ulcerative colitis and identifies {beta}HB as a potential therapeutic target.

bioRxiv · Aug 25, 2025 · PreprintCell Biology

Inflammation-associated monocytes express ACOD1 to curtail inflammatory behaviour in IBD and experimental colitis

Gareth‐Rhys Jones, Broc Drury, Tobi Alegbe, Monika Krzak, Lizi M. Hegarty, Tim Raine, Adam Bryne, Carl A. Anderson, Gwo‐Tzer Ho, Calum C. Bain

The paper identifies inflammation-associated monocytes (IAMs) in IBD and experimental colitis, showing they express ACOD1 to limit cytokine production during inflammation.

bioRxiv · Nov 15, 2024 · PreprintImmunology