Preserved striatal innervation and motor function despite severe loss of nigral dopamine neurons following mitochondrial dysfunction induced by mtDNA mutations
Thomas Paß, Konrad M. Ricke, Pierre Hofmann, Roy Chowdhury, Yu Nie, Patrick Francis Chinnery, Heike Endepols, Bernd Neumaier, Andre Ferrer Carvalho, Lionel Rigoux, Sophie Marie Steculorum, Julien Prudent, Trine Riemer, Markus Aswendt, Bent Brachvogel, Rudolf J. Wiesner
This study shows that mice with severe loss of nigral dopamine neurons due to mtDNA mutations still maintain motor function through preserved striatal innervation.
bioRxiv · Jul 7, 2023 · PreprintNeuroscience