Author

Yu Nie

University of CambridgeORCID 0000-0001-7670-6411Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Patrick Francis ChinneryiD· 2 shared András LakatosiD· 1 shared Andre Ferrer CarvalhoiD· 1 shared Bent BrachvogeliD· 1 shared Bernd NeumaieriD· 1 shared Camilla LyonsiD· 1 shared Daniel LagosiD· 1 shared Denisa HathaziiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Patrick Francis ChinneryORCID

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2 papers

Recent·Most cited

NeuroscienceDOAJ (DOAJ: Directory of Open Access Journals)Peer-reviewedJun 21, 2026

Mitochondrial DNA heteroplasmy drives cortical neuronal disturbances in human organoids harbouring the common m.3243A>G mutation

Denisa Hathazi, Camilla Lyons, Daniel Lagos…·Rita Horváth

This study shows that high mitochondrial DNA heteroplasmy in human organoids with the m.3243A>G mutation causes cortical neuronal disturbances, including axonal degeneration and apoptosis, similar to MELAS patients.

DOI 10.1038/s41467-026-74103-y

humanbulk RNA-seq

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NeurosciencebioRxivPreprintJul 7, 2023

Preserved striatal innervation and motor function despite severe loss of nigral dopamine neurons following mitochondrial dysfunction induced by mtDNA mutations

Thomas Paß, Konrad M. Ricke, Pierre Hofmann…·Rudolf J. Wiesner

This study shows that mice with severe loss of nigral dopamine neurons due to mtDNA mutations still maintain motor function through preserved striatal innervation.

2 citations

mousebulk RNA-seq

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