The subcommissural organ regulates brain development via secreted peptides
Tingting Zhang, Daosheng Ai, Pingli Wei, Ying Xu, Zhanying Bi, Fengfei Ma, Fengzhi Li, Xing-jun Chen, Zhaohuan Zhang, Xiaoxiao Zou, Zongpei Guo, Yue Zhao, Jun-Liszt Li, Meng Ye, Ziyan Feng, , Woo‐Ping Ge
The paper identifies three genes highly expressed in the subcommissural organ (SCO) and shows their ablation causes brain developmental defects, with peptide reintroduction rescuing these defects.
Nature Neuroscience · May 13, 2024Peer-reviewedNeuroscience