Woo‐Ping Ge

The paper characterizes the metabolomes of microglia, astrocytes, and neurons in aging and Alzheimer's brains, identifying cell-type-specific metabolic pathways and their changes with age and disease.

OpenFISH integrates spatial transcriptomics and metabolomics on a single tissue section, enabling cell-accurate co-registration and revealing metabolic heterogeneity and transcriptional changes in mouse brain.

The paper develops a rAAV vector, rAAV-miniBEND, for specific gene delivery to brain endothelial cells and models cerebrovascular malformations like CCM and AVM.

The paper introduces a curved light sheet microscope for high-throughput imaging of cleared tissues, achieving diffraction-limited resolution over a large field of view.

This study identifies metabolites cleared by cisternostomy in TBI patients, showing their correlation with clinical improvement.

The paper identifies three genes highly expressed in the subcommissural organ (SCO) and shows their ablation causes brain developmental defects, with peptide reintroduction rescuing these defects.

The paper introduces a method to map individual sensory nerve axons from digits to spinal cord at sub-micron resolution.

The paper shows ADAM10 regulates macroglial cell fate by promoting astrocyte generation and inhibiting oligodendrocyte production in developing brains.

This study maps the mouse brain metabolome using targeted metabolomics, creating detailed maps of 79 metabolites at high resolution.

This study shows that blood vessel regression in the brain reduces neuronal activity by impairing mitochondrial metabolism and glutamate production.

This paper develops vascularized human cortical organoids that model cortical development and show synaptic activity and integration potential in vivo.