Author

Xing-jun Chen

Peking UniversityORCID 0009-0004-7657-6070Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:differential expression· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Organism:rat· 1

Frequent Co-Authors

Wenzhi SuniD· 4 shared Woo‐Ping GeiD· 4 shared Daosheng Ai· 3 shared Jun-Liszt LiiD· 3 shared Ziyan Feng· 3 shared Fengzhi LiiD· 2 shared Xiaoxiao ZouiD· 2 shared Zhanying BiiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersNeuroscience

Wenzhi SunORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

rAAV-miniBEND: A targeted vector for brain endothelial cell gene delivery and cerebrovascular malformation modeling

Jun-Liszt Li, Zhanying Bi, Xing-jun Chen, Tianyue Ming, Baoshan Qiu, Fengzhi Li, Ziyan Feng, Daosheng Ai, Tingting Zhang, Jiayu Wang, Shuai Lin, Yiping Lu, Zhen Wang, Juan Huang, Fei Zhao, , Woo‐Ping Ge

The paper develops a rAAV vector, rAAV-miniBEND, for specific gene delivery to brain endothelial cells and models cerebrovascular malformations like CCM and AVM.

bioRxiv · Jun 10, 2025 · PreprintNeuroscience

Curved light sheet microscopy for centimeter-scale cleared tissues imaging

Lijuan Tang, Jiayu Wang, Jiayi Ding, Junyou Sun, Xing-jun Chen, Quqing Shen, Ruiheng Song, Peng Cao, Rong Gong, Fang Xu, Woo‐Ping Ge, Wenzhi Sun, Hu Zhao, Jianglai Wu

The paper introduces a curved light sheet microscope for high-throughput imaging of cleared tissues, achieving diffraction-limited resolution over a large field of view.

Nature Photonics · Apr 11, 2025Peer-reviewedBioengineering

The subcommissural organ regulates brain development via secreted peptides

Tingting Zhang, Daosheng Ai, Pingli Wei, Ying Xu, Zhanying Bi, Fengfei Ma, Fengzhi Li, Xing-jun Chen, Zhaohuan Zhang, Xiaoxiao Zou, Zongpei Guo, Yue Zhao, Jun-Liszt Li, Meng Ye, Ziyan Feng, , Woo‐Ping Ge

The paper identifies three genes highly expressed in the subcommissural organ (SCO) and shows their ablation causes brain developmental defects, with peptide reintroduction rescuing these defects.

Nature Neuroscience · May 13, 2024Peer-reviewedNeuroscience

ADAM10 mediates macroglial cell fate decisions in the developing brain

Yihui Wang, Yue Liang, Daosheng Ai, Jun-Liszt Li, Ziyan Feng, Zhibao Guo, Xing-jun Chen, Tingting Zhang, Xiaoxiao Zou, Junli Gao, Xiaofei Gao, Xiao-Ling Hu, Long‐Jun Wu, Wenzhi Sun, Suiqiang Zhu, , Woo‐Ping Ge

The paper shows ADAM10 regulates macroglial cell fate by promoting astrocyte generation and inhibiting oligodendrocyte production in developing brains.

bioRxiv · Feb 11, 2023 · PreprintNeuroscience