A Fungal Natural Product that Inhibits Plant Cellulose Biosynthesis by disrupting Cellulose Synthase Complexes
Zhongshou Wu, Lu Liu, Wenyu Han, Xingbo Cai, Pixian Xiao, Zuodong Sun, Chunsheng Yan, Silvana M. Reid, Yun Chen, Zhonghua Ma, Yi Tang, Steven E. Jacobsen
This paper identifies a fungal natural product, MDD, as a novel cellulose biosynthesis inhibitor that targets CESA1 and disrupts cellulose synthase complexes, enabling the development of multi-drug resistant crop varieties.
Proceedings of the National Academy of Sciences · Jun 9, 2026Peer-reviewedPlant Biology