Biosynthetic allene and alkyne formation by enzymatic prenyl demethylation
Mengting Liu, Masao Ōhashi, Wenyu Han, Qingyang Zhou, Kendall N. Houk, Yi Tang
The paper identifies two fungal P450 enzymes that catalyze oxidative demethylation of prenyl groups to form allenes and alkynes in natural products.
Nature Chemical Biology · Sep 15, 2026Peer-reviewedBiochemistry