An Interbacterial Cysteine Protease Toxin Inhibits Cell Growth by Targeting Type II DNA Topoisomerases GyrB and ParE
Pin-Yi Song, Chia-En Tsai, Yung-Chih Chen, Yuwen Huang, Po-Pang Chen, Tzu‐Haw Wang, Chao-Yuan Hu, Po-Yin Chen, Chuan Ku, Kuo‐Chiang Hsia, See‐Yeun Ting
The paper identifies Cpe1, an interbacterial cysteine protease toxin from E. coli, which inhibits bacterial growth by cleaving type II DNA topoisomerases GyrB and ParE, disrupting DNA replication and chromosome segregation.
PLoS Biology · May 27, 2025Peer-reviewedMicrobiology