REV7/FANCV Binds to CHAMP1 and Promotes Homologous Recombination Repair
Feng Li, Prabha Sarangi, Divya Iyer, Hanrong Feng, Lisa A. Moreau, Huy Q. Nguyen, Connor S. Clairmont, Alan D. D’Andrea
The paper shows that REV7-CHAMP1 complex promotes homologous recombination repair by inhibiting NHEJ and TLS repair pathways, and its overexpression in tumors correlates with poor prognosis.
Cell Reports · Aug 1, 2022Peer-reviewedMolecular Biology