Cancer BiologyMolecular CellPeer-reviewed
Disruption of Microhomology-mediated End-joining in Ewing Sarcoma
Shuhei Asada, Guangli Zhu, Jithma P. Abeykoon…·Alan D. D’Andrea
This paper shows that Ewing sarcoma cells have reduced POLθ expression and MMEJ activity due to EWS-FLI1 or EWSR1 disruption, making them sensitive to inhibitors of FA, NHEJ, or HR pathways.
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