Huy Q. Nguyen

This study identifies a defect in MMEJ repair in SMARCB1-deficient tumors, leading to hyper-dependence on the FA/BRCA pathway, which can be targeted for therapy.

The paper determines the first high-resolution crystal structures of CDK5-cyclin B1, revealing its mitotic activation mechanism similar to CDK1-cyclin B1.

This study identifies the CHAMP1 complex's role in heterochromatin assembly and its enhancement of homology-directed DNA repair in specific genomic regions.

The paper shows that REV7-CHAMP1 complex promotes homologous recombination repair by inhibiting NHEJ and TLS repair pathways, and its overexpression in tumors correlates with poor prognosis.