Author

Pragi Patel

The Ohio State University Wexner Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

Christopher M. BobbaiD· 2 shared Hyunwook LeeiD· 2 shared John William ChristmaniD· 2 shared Joshua A. EnglertiD· 2 shared Qinqin FeiiD· 2 shared Rachel K. PutmaniD· 2 shared Samir N. GhadialiiD· 2 shared Adam StreicheriD· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersMolecular Biology

Christopher M. BobbaORCID

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2 papers

Recent·Most cited

Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates lung injury during mechanical ventilation

Christopher M. Bobba, Qinqin Fei, Vasudha C. Shukla, Hyunwook Lee, Pragi Patel, Rachel K. Putman, CARLEEN M SPITZER, MuChun Tsai, Mark Damian Wewers, Robert J. Lee, John William Christman, Megan N. Ballinger, Samir N. Ghadiali, Joshua A. Englert

This study shows that overexpressing miR-146a via nanoparticles reduces lung injury during mechanical ventilation by targeting mechanotransduction in macrophages.

Nature Communications · Jan 12, 2021Peer-reviewedMolecular Biology

Mechanosensitive activation of mTORC1 mediates ventilator induced lung injury during the acute respiratory distress syndrome

Hyunwook Lee, Qinqin Fei, Adam Streicher, Wenjuan Zhang, Colleen Isabelle, Pragi Patel, Hilaire Colletta Lam, Miguel Pinilla-Vera, Diana Patricia Amador-Munoz, Diana Barragan-Bradford, Angelica Higuera, Rachel K. Putman, Elizabeth P. Henske, Christopher M. Bobba, Natalia Higuita‐Castro, , Joshua A. Englert

This study shows that mTORC1 activation during mechanical ventilation worsens lung injury in ARDS and that inhibiting mTORC1 can prevent ventilator-induced lung injury.

bioRxiv · Mar 2, 2020 · PreprintMolecular Biology