Robert J. Lee

This study investigates the role of cyclic-AMP/phosphodiesterase signaling in modulating nasal tuft cell calcium responses and IL-25 release using mouse and human models.

The paper identifies ciliary proteins that regulate melanogenesis in melanocytes and reveals moonlighting roles for Joubert Syndrome proteins in endolysosomal organization.

This study identifies MS4A8B as a regulator of Orai1-dependent Ca2+ influx in human nasal epithelial cilia, linking it to ciliary function and mucociliary clearance.

This study shows caffeine enhances cisplatin sensitivity in HNSCC by increasing TAS2R10 expression and reducing ABCG2 expression.

This study shows that 3-oxo-C12HSL from Pseudomonas aeruginosa induces apoptosis in HNSCC cells via T2R14 and mitochondrial calcium uniporter.

This study investigates the effects of pyocyanin and 1-hydroxyphenazine on calcium signaling, mitochondrial function, and cell viability in nasal epithelial cells and cancer cell lines.

Phendione, a T2R5 agonist, reduces cell viability and induces apoptosis in HNSCC cells and tumor samples, with T2R5 expression linked to better survival in HNSCC.

This study shows quercetin activates T2R14 in HNSCC cells, causing calcium responses, reduced viability, and mitochondrial depolarization.

This study shows bitter taste receptor agonists induce apoptosis in papillary thyroid cancer cells and higher TAS2R14 expression correlates with better patient survival.

This study shows that overexpressing miR-146a via nanoparticles reduces lung injury during mechanical ventilation by targeting mechanotransduction in macrophages.