Therapeutic targeting of Syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers
Madelaine Skolastika Theardy, Mitsunobu Takeda, Alexey V. Sorokin, Shuaitong Chen, Zecheng Yang, Xiaofei Wang, Preeti Kanikarla, Oluwadara Coker, Phuoc Thi-My Nguyen, Yongkun Wei, Jun Yao, Yan Liang, Yanqing Jin, Yiming Cai, Masakatsu Paku, , Wantong Yao
This study identifies the YAP1-SDC1 axis as a driver of resistance to mKRAS inhibitors in gastrointestinal cancers and suggests targeting this axis to overcome resistance.
Cell Reports Medicine · Jul 25, 2025Peer-reviewedCancer Biology