Author
The University of Texas MD Anderson Cancer CenterORCID 0009-0000-7195-6868Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Hey Min Lee, Zhao Zheng, Alexey V. Sorokin…·Scott Kopetz
This study shows BET + MAPK inhibitors improve efficacy against BRAFV600E CRC by inducing epigenetic reprogramming and cellular plasticity through enhancer dynamics disruption.
Madelaine Skolastika Theardy, Mitsunobu Takeda, Alexey V. Sorokin…·Wantong Yao
This study identifies the YAP1-SDC1 axis as a driver of resistance to mKRAS inhibitors in gastrointestinal cancers and suggests targeting this axis to overcome resistance.
Oscar Eduardo. Villarreal, Yixin Xu, Ha Tran…·Scott Kopetz
The paper identifies adaptive plasticity tumor (APT) cells that reduce response to MAPK inhibitors in colorectal cancer by increasing stemness and ASCL2 expression, and shows that targeting APT cells improves therapy efficacy.