Hypoxia-Mediated Molecular Interactions of Tissue-Specific Mesenchymal Stem Cells Drive Metabolic Reprogramming and Immunomodulation in Acute Graft-versus-Host Disease
Mohini Mendiratta, Meenakshi Mendiratta, Lakshay Malhotra, Sandeep Rai, Vijaya Sarangathem, Prince Dahiya, Ritu Gupta, Sameer Bakhshi, Vatsla Dadhwal, Deepam Pushpam, Mukul Aggarwal, Aditya Gupta, Prabhat Singh Malik, Raja Pramanik, Manoranjan Mahapatra, , Ranjit Kumar Sahoo
This study compares the immunomodulatory effects of hypoxia-preconditioned bone marrow and Wharton's jelly mesenchymal stem cells in acute graft-versus-host disease, finding WJ-MSCsHYP more effective due to enhanced mitochondrial transfer and metabolic reprogramming.
bioRxiv · Jan 6, 2025 · PreprintImmunology