This study optimizes the dose and timing of MSC-derived culture-conditioned media (CCM) to enhance its immunomodulatory effects on CD3+ T-cells in acute graft-versus-host disease.

Regenerative Therapy · Oct 9, 2025Peer-reviewedImmunology

The HOTAIRM1-miR-222 Axis Regulates Venetoclax Resistance and Defines a High-Risk Subset in Pediatric t(8;21) Acute Myeloid Leukemia

Christine Wilson, Priyanka Swaroop, Vikas Gaur, Diwakar Sharma, Tanuja Bhardwaj, Sachin Kumar, Anita Chopra, Sampa Ghose, Jayanth Kumar Palanichamy, Deepam Pushpam, Ranjit Kumar Sahoo, Sameer Bakhshi, Surender Kumar Sharawat

The paper identifies HOTAIRM1-miR-222 axis as a regulator of venetoclax resistance and a marker of high-risk t(8;21) AML in pediatric patients.

bioRxiv · Jul 12, 2025 · PreprintCancer Biology

Predictive Modeling of acute Graft-versus-Host-Disease using Machine Learning on Immune Cell and Cytokine Profiles at Engraftment

Mohini Mendiratta, Praful Pandey, Shobhit Pandey, Sandeep Rai, Shuvadeep Ganguly, Archana Sasi, Ritu Gupta, Prabhat Singh Malik, Raja Pramanik, Sachin Kumar, Baibaswata Nayak, Ruquaya Mir, Sameer Bakhshi, Deepam Pushpam, Mukul Aggarwal, , Ranjit Kumar Sahoo

This study uses machine learning to predict acute Graft-versus-Host-Disease (aGvHD) based on immune cell and cytokine profiles at engraftment, finding high accuracy with cytokine and T-cell data.

bioRxiv · Mar 13, 2025 · PreprintImmunology

Hypoxia-Mediated Molecular Interactions of Tissue-Specific Mesenchymal Stem Cells Drive Metabolic Reprogramming and Immunomodulation in Acute Graft-versus-Host Disease

Mohini Mendiratta, Meenakshi Mendiratta, Lakshay Malhotra, Sandeep Rai, Vijaya Sarangathem, Prince Dahiya, Ritu Gupta, Sameer Bakhshi, Vatsla Dadhwal, Deepam Pushpam, Mukul Aggarwal, Aditya Gupta, Prabhat Singh Malik, Raja Pramanik, Manoranjan Mahapatra, , Ranjit Kumar Sahoo

This study compares the immunomodulatory effects of hypoxia-preconditioned bone marrow and Wharton's jelly mesenchymal stem cells in acute graft-versus-host disease, finding WJ-MSCsHYP more effective due to enhanced mitochondrial transfer and metabolic reprogramming.

bioRxiv · Jan 6, 2025 · PreprintImmunology

Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease

Mohini Mendiratta, Meenakshi Mendiratta, Shuvadeep Ganguly, Sandeep Rai, Ritu Gupta, Lalit Kumar, Sameer Bakhshi, Vatsla Dadhwal, Deepam Pushpam, Prabhat Singh Malik, Raja Pramanik, Mukul Aggarwal, Aditya Gupta, Rishi Dhawan, Tulika Seth, , Ranjit Kumar Sahoo

This study shows that hypoxia and apoptosis conditioning of WJ-MSCs enhances their immune regulatory capacity in aGVHD by promoting Treg differentiation and M2 macrophage polarization.

Stem Cell Research & Therapy · Oct 29, 2024Peer-reviewedImmunology