Dual Preconditioned Mesenchymal Stem Cells-Derived Culture Conditioned Media Augment Immunomodulation and Drive Metabolic Reprogramming in Acute Graft-versus-Host Disease
Mohini Mendiratta, Meenakshi Mendiratta, Sandeep Rai…·Ranjit Kumar Sahoo
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All India Institute of Medical SciencesORCID 0000-0003-0280-5833Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
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Mohini Mendiratta, Meenakshi Mendiratta, Sandeep Rai…·Ranjit Kumar Sahoo
Mohini Mendiratta, Meenakshi Mendiratta, Sujata Mohanty…·Ranjit Kumar Sahoo
This study optimizes the dose and timing of MSC-derived culture-conditioned media (CCM) to enhance its immunomodulatory effects on CD3+ T-cells in acute graft-versus-host disease.
Mohini Mendiratta, Meenakshi Mendiratta, Lakshay Malhotra…·Ranjit Kumar Sahoo
This study compares the immunomodulatory effects of hypoxia-preconditioned bone marrow and Wharton's jelly mesenchymal stem cells in acute graft-versus-host disease, finding WJ-MSCsHYP more effective due to enhanced mitochondrial transfer and metabolic reprogramming.
Mohini Mendiratta, Meenakshi Mendiratta, Shuvadeep Ganguly…·Ranjit Kumar Sahoo
This study shows that hypoxia and apoptosis conditioning of WJ-MSCs enhances their immune regulatory capacity in aGVHD by promoting Treg differentiation and M2 macrophage polarization.
Sushil Bhandari, Padma Dolma, Mitali Mukerji…·Sara L. Hillman
The paper investigates birth weight in a high altitude Ladakhi population using GWAS and ancestry analysis, finding evidence of Tibetan ancestry and nominal associations with birthweight-related genes.