Author

Prithi A Srinivasan

University of Chicago

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alexander J. RuthenburgiD· 2 shared Amanda J. KeplingeriD· 2 shared Beatrix M. UeberheideiD· 1 shared Cristian SuareziD· 1 shared Juliana Ortiz-PachecoiD· 1 shared Sarah M. ChristenseniD· 1 shared Tyler C. CropleyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersMolecular Biology

Alexander J. RuthenburgORCID

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2 papers

Recent·Most cited

Bound for the nucleus: defining the molecular principles of cargo selection by importin 9

Amanda J. Keplinger, Tyler C. Cropley, Juliana Ortiz-Pacheco, Prithi A Srinivasan, Alexander J. Ruthenburg, Beatrix M. Ueberheide

This study identifies 79 cargos bound by IPO9, showing it recognizes proteins without cNLSs, and defines structural elements that mediate cargo selection and release.

bioRxiv · May 14, 2026 · PreprintMolecular Biology

A revised model of nuclear actin import: Importin 9 competes with cofilin, profilin, and RanGTP for actin binding

Amanda J. Keplinger, Prithi A Srinivasan, Sarah M. Christensen, Cristian Suarez, Alexander J. Ruthenburg

This paper challenges the established model of actin import by showing IPO9 directly binds monomeric actin and competes with cofilin and profilin for actin binding.

Journal of Biological Chemistry · Dec 31, 2025Peer-reviewedBiochemistry