Author

Amanda J. Keplinger

University of ChicagoORCID 0000-0002-5959-9703Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:protein structure prediction· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:protein design· 1

Frequent Co-Authors

Alexander J. RuthenburgiD· 3 shared Prithi A Srinivasan· 2 shared Beatrix M. UeberheideiD· 1 shared Cristian SuareziD· 1 shared Jane J. Rosin· 1 shared Jimmy EliasiD· 1 shared Juliana Ortiz-PachecoiD· 1 shared Sarah M. ChristenseniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 18 mutual co-author links

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3 shared papersMolecular Biology

Alexander J. RuthenburgORCID

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3 papers

Recent·Most cited

Bound for the nucleus: defining the molecular principles of cargo selection by importin 9

Amanda J. Keplinger, Tyler C. Cropley, Juliana Ortiz-Pacheco, Prithi A Srinivasan, Alexander J. Ruthenburg, Beatrix M. Ueberheide

This study identifies 79 cargos bound by IPO9, showing it recognizes proteins without cNLSs, and defines structural elements that mediate cargo selection and release.

bioRxiv · May 14, 2026 · PreprintMolecular Biology

A revised model of nuclear actin import: Importin 9 competes with cofilin, profilin, and RanGTP for actin binding

Amanda J. Keplinger, Prithi A Srinivasan, Sarah M. Christensen, Cristian Suarez, Alexander J. Ruthenburg

This paper challenges the established model of actin import by showing IPO9 directly binds monomeric actin and competes with cofilin and profilin for actin binding.

Journal of Biological Chemistry · Dec 31, 2025Peer-reviewedBiochemistry

The N-terminus of YY1 regulates DNA and RNA binding affinity for both the zinc-fingers and an unexpected nucleic acid binding domain

Jimmy Elias, Jane J. Rosin, Amanda J. Keplinger, Alexander J. Ruthenburg

This study identifies two RNA binding domains in YY1, including a newly discovered nucleic acid binding domain, and reveals autoinhibitory effects of the N-terminus on these domains.

bioRxiv · Oct 4, 2024 · PreprintMolecular Biology