Exploration of targeted electrophilic kinase probes identifies a covalent ULK1 degrader
Nur Mehpare Kocatürk, Adam L. Pinto, Matylda Anna Izert, Léa P. Wilhelm, Gajanan J. Sathe, Qasim Ashraf, Ian G. Ganley, Adrien Rousseau, William Farnaby
The paper identifies covalent ULK1 degraders by modifying ATP-site binding scaffolds to control ULK1 activity and abundance.
bioRxiv · May 5, 2026 · PreprintBiochemistry