Evolution of the Spatial transcriptomic landscape during the progression of high-grade pancreatic intraductal papillary mucinous neoplasms to invasive cancer
Sirui Peng, Qiangxing Chen, Zixin Chen, Mengling Yao, Yunqiang Cai, Du He, Yu Cai, Ke Cheng, Jun Li, He Cai, Pan Gao, Xiafei Gu, Xin Wang, Yongbin Li, Man Zhang, , Bing Peng
This study uses spatial transcriptomics to analyze the progression of high-grade IPMN to invasive PDAC, identifying clonal evolution, key drivers, immune shifts, and CAF roles.
Pancreatology · Dec 19, 2025Peer-reviewedCancer Biology