Cancer BiologyScience SignalingPeer-reviewed
Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK-driven lung cancer via concurrent integrin and MET signaling
Qianqian Hu, Lily L. Remsing Rix, Bina Desai…·Uwe Rix
This study identifies that CAFs confer ALK inhibitor resistance in EML4-ALK-driven lung cancer through both MET and integrin signaling pathways, and shows that targeting both pathways improves treatment efficacy.
6 citations