Cancer-associated fibroblasts confer ALK inhibitor resistance in EML4-ALK-driven lung cancer via concurrent integrin and MET signaling
Qianqian Hu, Lily L. Remsing Rix, Bina Desai, Daria Miroshnychenko, Xueli Li, Eric A. Welsh, Bin Fang, Gabriela M. Wright, Neelkamal Chaudhary, Jodi L. Kroeger, Robert Charles Doebele, John M. Koomen, Eric B. Haura, Andriy Marusyk, Uwe Rix
This study identifies that CAFs confer ALK inhibitor resistance in EML4-ALK-driven lung cancer through both MET and integrin signaling pathways, and shows that targeting both pathways improves treatment efficacy.
Science Signaling · Dec 23, 2025Peer-reviewedCancer Biology