OPUS-ET: Resolving Compositional and Conformational Heterogeneities of Biomolecules in Cryo-Electron Tomography
Zhenwei Luo, Xiangru Chen, Qinghua Wang, Jianpeng Ma
OPUS-ET improves cryo-ET resolution by resolving compositional and conformational heterogeneities using a deep learning framework, achieving sub-nanometer reconstructions and revealing structural dynamics in biomolecules.
bioRxiv · Nov 21, 2025 · PreprintMolecular Biology