Isogenic monocytes improve the responsiveness of hiPSC cardiac spheroids to cardiac stressors
Elisabeth Tamara Strässler, Elise L. Kessler, Emile F. van Vliet, Nino Chirico, Ellen Na, Qingqing Cai, Alain van Mil, Gabriele G. Schiattarella, Holger Gerhardt, Nicolle Kränkel, Saskia C.A. de Jager, Joost P. G. Sluijter, Ulf Landmesser
The paper develops a cardiac spheroid model with monocytes to better mimic heart failure responses, showing improved functional and transcriptional changes compared to models without immune cells.
bioRxiv · Oct 16, 2025 · PreprintCell Biology