Saskia C.A. de Jager

NEO-AAV: an engineered extracellular vesicle-enveloped AAV platform for activation-coupled T cell transduction and CAR-T cell generation

This paper introduces NEO-AAV, an engineered AAV platform that enhances T cell transduction and CAR-T cell generation by enveloping AAV in extracellular vesicles, improving immune resistance and transduction efficiency.

Isogenic monocytes improve the responsiveness of hiPSC cardiac spheroids to cardiac stressors

The paper develops a cardiac spheroid model with monocytes to better mimic heart failure responses, showing improved functional and transcriptional changes compared to models without immune cells.

AAV6-HCN4t-mediated biological pacing as a potential life-saving therapy for congenital complete heart block

This study develops AAV6-HCN4t gene therapy to enhance biological pacing in complete heart block, showing sustained effects in rats and pigs.