Ulf Landmesser

This study identifies endothelial YAP/TAZ signaling as a driver of sex-divergent vascular remodeling in HFpEF, linking cardiometabolic stress to microvascular changes through YAP1 and ESM1.

The paper develops a cardiac spheroid model with monocytes to better mimic heart failure responses, showing improved functional and transcriptional changes compared to models without immune cells.

This study shows that gut microbial metabolite imidazole propionate impairs endothelial function and promotes atherosclerosis in both human and animal models.

This study shows that pneumonia increases glucagon levels, which damages endothelial cells and promotes blood clotting, leading to cardiovascular issues.

The paper identifies HLA-C* 04:01 as a genetic risk allele associated with increased intubation risk in severe COVID-19 cases, validated across multiple cohorts.

The paper develops a DIA-based proteotyping strategy for HDL particles, revealing significant proteotype differences between healthy individuals and those with T2DM or CHD.