P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi
Michal Caspi Tal, Paige S. Hansen, Haley A. Ogasawara, Qingying Feng, Regan F. Volk, Brandon Hochahn Lee, Sara E. Casebeer, Grace Blacker, Maia Shoham, Sarah Galloway, Anne L. Sapiro, Beth M. Hayes, Laughing Bear Torrez Dulgeroff, Tal Raveh, Venkata Raveendra Pothineni, , Balyn W. Zaro
This study identifies P66, a bacterial protein mimicking CD47, which binds SIRPα to evade macrophage phagocytosis, and shows its role in Lyme Disease pathogenesis.
bioRxiv · Apr 29, 2024 · PreprintImmunology