Michal Caspi Tal

This study identifies P66, a bacterial protein mimicking CD47, which binds SIRPα to evade macrophage phagocytosis, and shows its role in Lyme Disease pathogenesis.

This study shows that the CD47-SIRP axis regulates platelet homeostasis and that blocking this interaction affects platelet levels in mice and humans.

The paper identifies a genetic variant in SCGB1D2 that increases Lyme disease susceptibility and shows that the wild-type protein inhibits Borrelia burgdorferi growth more effectively than the variant.