Tau Disaggregation by a CNS-Permeable Small Molecule Reduces Fibril and Oligomer Burden and Preserves Proteostasis and Behavior
Nader Mostowfi, Ryan Patrick Foreman, Jinliang Wang, Rachel Khoury, Angela Albanese, Qiulan L Ma, Whitaker Cohn, Giselle Maria Petzinger, Michael Walter Jakowec, Syed Ahmed, Paul M. Seidler
This paper develops a small molecule that disaggregates tau fibrils and oligomers, reduces pathology, and preserves function in a tauopathy mouse model.
bioRxiv · Sep 1, 2026 · PreprintNeuroscience