Giselle Maria Petzinger

Tau Disaggregation by a CNS-Permeable Small Molecule Reduces Fibril and Oligomer Burden and Preserves Proteostasis and Behavior

This paper develops a small molecule that disaggregates tau fibrils and oligomers, reduces pathology, and preserves function in a tauopathy mouse model.

Uncovering locomotor learning dynamics in people with Parkinson's disease

This study investigates locomotor learning in people with Parkinson's disease using a virtual obstacle task, finding faster learning rates in PD patients compared to controls.

Exercise alters cortico-basal ganglia network functional connectivity: A mesoscopic level analysis informed by anatomic parcellation defined in the mouse brain connectome

This study examines how exercise affects functional connectivity in the cortico-basal ganglia network in mice, revealing changes in connectivity patterns and metabolic activity in specific brain regions.

Knockdown of astrocytic monocarboxylate transporter 4 (MCT4) in the motor cortex leads to loss of dendritic spines and a deficit in motor learning

This study shows that knocking down astrocytic MCT4 in the motor cortex impairs motor learning and reduces dendritic spines and neuronal activity.

Exogenous L-lactate promotes astrocyte plasticity but is not sufficient for enhancing striatal synaptogenesis or motor learning in mice

This study shows L-lactate increases astrocyte plasticity-related gene expression but does not enhance striatal synaptogenesis or motor learning in mice.