Michael Walter Jakowec

Tau Disaggregation by a CNS-Permeable Small Molecule Reduces Fibril and Oligomer Burden and Preserves Proteostasis and Behavior

This paper develops a small molecule that disaggregates tau fibrils and oligomers, reduces pathology, and preserves function in a tauopathy mouse model.

Ivermectin increases striatal cholinergic activity to facilitate dopamine terminal function

This study shows that ivermectin enhances striatal dopamine release by increasing cholinergic activity, not through vesicular content changes.

Exercise alters cortico-basal ganglia network functional connectivity: A mesoscopic level analysis informed by anatomic parcellation defined in the mouse brain connectome

This study examines how exercise affects functional connectivity in the cortico-basal ganglia network in mice, revealing changes in connectivity patterns and metabolic activity in specific brain regions.

Knockdown of astrocytic monocarboxylate transporter 4 (MCT4) in the motor cortex leads to loss of dendritic spines and a deficit in motor learning

This study shows that knocking down astrocytic MCT4 in the motor cortex impairs motor learning and reduces dendritic spines and neuronal activity.

Exogenous L-lactate promotes astrocyte plasticity but is not sufficient for enhancing striatal synaptogenesis or motor learning in mice

This study shows L-lactate increases astrocyte plasticity-related gene expression but does not enhance striatal synaptogenesis or motor learning in mice.