Transcription-associated topoisomerase activities control DNA-breaks production by G-quadruplex ligands
Angélique Pipier, Madeleine Bossaert, Jean‐François Riou, Céline Noirot, L-T. Nguyễn, R-F. Serre, Olivier Bouchez, Éric Defrancq, Patrick Calsou, Sébastien Britton, Dennis Gómez
The paper identifies TOP2A as a key effector of cytotoxicity from G4 ligands and shows its role in DNA break production during transcription.
bioRxiv · Feb 18, 2020 · PreprintMolecular Biology