Author

Madeleine Bossaert

Centre National de la Recherche ScientifiqueORCID 0000-0002-8792-6783Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Sébastien BrittoniD· 3 shared Dennis GómeziD· 2 shared Patrick CalsouiD· 2 shared Philippe FritiD· 2 shared Alexandrine Rozié· 1 shared Andrew Moreno· 1 shared Angélique PipieriD· 1 shared António PeixotoiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

Sébastien BrittonORCID

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3 papers

Recent·Most cited

Exploiting HSD17B11-dependent dialkynylcarbinols cytotoxicity for facile CRISPR/Cas9-based gene inactivation

Bastien Dumais, Madeleine Bossaert, Patrick Seigneur, Alexandrine Rozié, Sophie Gasmi, Luce Fontanié--Roger, Maëlle Caroff, Valérie Maraval, Vania Bernardes‐Génisson, Dennis Gómez, Philippe Frit, Stéphanie Ballereau, Yves Génisson, Sébastien Britton

The paper demonstrates that inactivating HSD17B11 confers resistance to PAC, enabling efficient CRISPR/Cas9-based gene inactivation through PAC selection.

bioRxiv · Sep 20, 2026 · PreprintMolecular Biology

Identification of the main barriers to Ku accumulation in chromatin

Madeleine Bossaert, Andrew Moreno, António Peixoto, Marie‐Jeanne Pillaire, Pauline Chanut, Philippe Frit, Patrick Calsou, Joseph J. Loparo, Sébastien Britton

The paper identifies mechanisms that limit Ku protein accumulation in chromatin, showing DNA-PKcs blocks Ku entry, and two additional mechanisms restrict Ku levels in the absence of DNA-PKcs.

Cell Reports · Jul 26, 2024Peer-reviewedMolecular Biology

Transcription-associated topoisomerase activities control DNA-breaks production by G-quadruplex ligands

Angélique Pipier, Madeleine Bossaert, Jean‐François Riou, Céline Noirot, L-T. Nguyễn, R-F. Serre, Olivier Bouchez, Éric Defrancq, Patrick Calsou, Sébastien Britton, Dennis Gómez

The paper identifies TOP2A as a key effector of cytotoxicity from G4 ligands and shows its role in DNA break production during transcription.

bioRxiv · Feb 18, 2020 · PreprintMolecular Biology