Patrick Calsou

The paper shows PAXX and XLF have sequential roles in stabilizing and maturing the NHEJ synaptic complex through distinct interactions.

The paper identifies PERIOD proteins as regulators of TC-DSB repair by anchoring DSBs to the nuclear envelope, linking circadian rhythms to DNA repair mechanisms.

This study identifies how DNA polymerase Lambda interacts with the NHEJ complex via Ku70/80, revealing the molecular basis for its recruitment and activity in DNA repair.

The paper identifies mechanisms that limit Ku protein accumulation in chromatin, showing DNA-PKcs blocks Ku entry, and two additional mechanisms restrict Ku levels in the absence of DNA-PKcs.

The paper identifies Ku-binding motifs in RAG2, XLF, PAXX, and MRI that mediate their interactions with Ku and support functional redundancy during V(D)J recombination.

The paper identifies TOP2A as a key effector of cytotoxicity from G4 ligands and shows its role in DNA break production during transcription.