Sébastien Britton

Exploiting HSD17B11-dependent dialkynylcarbinols cytotoxicity for facile CRISPR/Cas9-based gene inactivation

The paper demonstrates that inactivating HSD17B11 confers resistance to PAC, enabling efficient CRISPR/Cas9-based gene inactivation through PAC selection.

Sequential division of labor between PAXX and XLF drives NHEJ synaptic complex stability and maturation

The paper shows PAXX and XLF have sequential roles in stabilizing and maturing the NHEJ synaptic complex through distinct interactions.

Selective Disruption of Plasmodium falciparum mitochondrial DNA via G-Quadruplex-Binding Ligand RHPS4 Provides a Novel Antimalarial Strategy

This study shows RHPS4, a G-quadruplex ligand, disrupts Plasmodium falciparum mitochondrial DNA and metabolism, offering a new antimalarial strategy by targeting mtDNA G4 structures.

DNA polymerase Lambda is anchored within the NHEJ synaptic complex via Ku70/80

This study identifies how DNA polymerase Lambda interacts with the NHEJ complex via Ku70/80, revealing the molecular basis for its recruitment and activity in DNA repair.

Patching up the nucleus: a novel role for PMLII in nuclear envelope rupture repair

This study identifies PMLII as forming biomolecular condensates at sites of nuclear envelope disruption, suggesting a role in stabilizing the site for repair.

Identification of the main barriers to Ku accumulation in chromatin

The paper identifies mechanisms that limit Ku protein accumulation in chromatin, showing DNA-PKcs blocks Ku entry, and two additional mechanisms restrict Ku levels in the absence of DNA-PKcs.

XAB2 prevents abortive recombinational repair of replication-associated DNA double-strand breaks and its loss is synthetic lethal with RAD52 inhibition

Transcription-associated topoisomerase activities control DNA-breaks production by G-quadruplex ligands

The paper identifies TOP2A as a key effector of cytotoxicity from G4 ligands and shows its role in DNA break production during transcription.