Dennis Gómez

The paper demonstrates that inactivating HSD17B11 confers resistance to PAC, enabling efficient CRISPR/Cas9-based gene inactivation through PAC selection.

This study shows RHPS4, a G-quadruplex ligand, disrupts Plasmodium falciparum mitochondrial DNA and metabolism, offering a new antimalarial strategy by targeting mtDNA G4 structures.

This study develops an antibody that selectively recognizes the antiparallel topology of human telomeric G-quadruplex DNA, distinguishing it from parallel conformations.

This study investigates how iMab binds to cytosine-rich DNA sequences and unfolds i-Motifs, showing it binds to 2-3 cytosine blocks and unfolds iMs in acidic conditions.

The paper identifies TOP2A as a key effector of cytotoxicity from G4 ligands and shows its role in DNA break production during transcription.