B. K. Chen

Hypoxia-sensing by the Histone Demethylase UTX (KDM6A) Controls Colitogenic CD4+ T cell Fate and Mucosal Inflammation

This study shows that UTX, an oxygen-sensitive histone demethylase, modulates colitis severity by affecting CD4+ T cell function and epigenetic regulation under hypoxia.

Traumatic brain injury-induced fear generalization in mice involves hippocampal memory trace dysfunction and is alleviated by (R,S)-ketamine

This study shows that traumatic brain injury in mice causes fear generalization through hippocampal memory trace dysfunction, which is reduced by (R,S)-ketamine.

Non-neutralizing antibodies targeting the immunogenic regions of HIV-1 envelope reduce mucosal infection and virus burden in humanized mice

This study shows that non-neutralizing antibodies targeting HIV-1 envelope regions reduce mucosal infection and virus burden in humanized mice through Fc-mediated effector functions.

Recruitment of Env to the HIV-1 T cell virological synapse by targeted and sustained Env recycling

This study investigates how HIV-1 Env is recruited and retained at the virological synapse through targeted recycling rather than irreversible interactions.

P2X1 selective antagonists block HIV-1 infection through inhibition of envelope conformation-dependent fusion

This paper shows P2X1 antagonists block HIV-1 infection by inhibiting envelope conformation-dependent fusion across multiple viral clades.

P2X antagonists inhibit HIV-1 productive infection and inflammatory cytokines IL-10 and IL-1β in a human tonsil explant model

Anti-α4β7 therapy targets lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals

Anti-α4β7 therapy reduces lymphoid aggregates in the gastrointestinal tract of HIV-1 infected individuals with mild inflammatory bowel disease.