R. A. M. de Bruin

This study shows c-Myc increases cellular tolerance to proteotoxic and genotoxic stress by upregulating HSF1, which supports cell survival under c-Myc-induced stress conditions.

This study identifies active mTOR signaling and cell growth as predictors of cancer cell sensitivity to the CDK7 inhibitor ICEC0942.

This study identifies a novel mechanism by which c-Myc induces replication stress through increased chromatin-bound cohesins in the G1 phase.

This study investigates how vaccinia virus affects host cell cycle progression and proliferation, identifying viral effectors responsible for cell cycle inhibition and shift.

This study identifies proteasome-mediated degradation of CdvB as a mechanism resetting the cell division cycle and triggering cytokinesis in the archaeon Sulfolobus acidocaldarius.