Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training.
M. R. Viggars, H. E. Berko, S. J. Hesketh, C. A. Wolff, M. A. Gutierrez Monreal, R. A. Martin, I. G. Jennings, Z. Huo, K. A. Esser
This study shows that BMAL1 in skeletal muscle is essential for transcriptional responses to exercise and peripheral tissue adaptations, with its loss leading to divergent transcriptomic and metabolomic changes and increased inflammation.
bioRxiv · Oct 13, 2023Physiology