S. J. Hesketh

Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training.

This study shows that BMAL1 in skeletal muscle is essential for transcriptional responses to exercise and peripheral tissue adaptations, with its loss leading to divergent transcriptomic and metabolomic changes and increased inflammation.

Morning endurance training induces superior performance adaptations compared to afternoon training in mice

This study shows that morning endurance training in mice leads to better performance adaptations than afternoon training, despite lower training volumes.

IFT-A Structure Reveals Carriages for Membrane Protein Transport into Cilia

The paper determines the structure of the human IFT-A complex using cryo-EM and shows its role in membrane protein transport into cilia via interactions with TULP adaptors.