Strong paracrine effects of SASP from senescence-induced severe early-onset COPD-derived fibroblasts
R. A. Meuleman, W. Timens, W. Kooistra, M. van den Berge, C.-A. Brandsma, R. R. Woldhuis
This study shows that SASP from senescent fibroblasts in severe early-onset COPD promotes paracrine senescence, inflammation, and ECM dysregulation in surrounding fibroblasts.
bioRxiv · Sep 1, 2023 · PreprintCell Biology