Author

M. van den Berge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 2 Immunology· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Organism:human· 8 Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

C.-A. Brandsma· 4 shared W. Timens· 4 shared M. C. Nawijn· 3 shared R. R. Woldhuis· 3 shared B. M. ter Ellen· 2 shared B. Troost· 2 shared D. P. I. van de Pol· 2 shared D. van Gosliga· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersCell Biology

C.-A. Brandsma

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Interpretable Inflammation Landscape of Circulating Immune cells

L. Jimenez-Gracia, D. Maspero, S. Aguilar-Fernandez, F. Craighero, M. Boulougouri, M. Ruiz, D. Marchese, G. Caratu, J. Linares-Blanco, M. Berasategi, R. O. Ramirez Flores, A. Sanzo-Machuca, A. M. Corraliza, H. A. Tran, R. Normand, , Na

This paper constructs a single-cell atlas of circulating immune cells to understand inflammation across diseases and develops a classifier for inflammatory diseases.

bioRxiv · Nov 28, 2023Immunology

Strong paracrine effects of SASP from senescence-induced severe early-onset COPD-derived fibroblasts

R. A. Meuleman, W. Timens, W. Kooistra, M. van den Berge, C.-A. Brandsma, R. R. Woldhuis

This study shows that SASP from senescent fibroblasts in severe early-onset COPD promotes paracrine senescence, inflammation, and ECM dysregulation in surrounding fibroblasts.

bioRxiv · Sep 1, 2023 · PreprintCell Biology

E-cigarette vapour induces cellular senescence in primary lung fibroblasts and may contribute to lung pathology

J. Bozier, B. Wang, M. de Vries, C.-A. Brandsma, M. van den Berge, W. Timens, I. H. Heijink, B. G. G. Oliver, R. R. Woldhuis

This study shows E-cigarette vapour induces cellular senescence in primary human lung fibroblasts, impairing tissue repair, but not in a mouse model.

bioRxiv · Aug 30, 2023 · PreprintCell Biology

Cellular Senescence Affects ECM Regulation in COPD Lung Tissue

R. R. Woldhuis, N. J. Bekker, J. L. L. Nijnatten, M. Banchero, W. Kooistra, K. J. C. Wolters, P. L. Horvatovich, V. Guryev, M. van den Berge, W. Timens, C.-A. Brandsma

This study identifies ECM gene and protein changes in COPD lung tissue linked to cellular senescence, confirming in vivo associations previously observed in vitro.

bioRxiv · Aug 2, 2023 · PreprintPathology

Moxidectin and ivermectin inhibit SARS-CoV-2 replication in Vero E6 cells but not in human primary airway epithelium cells

N. Dinesh Kumar, B. M. ter Ellen, E. M. Bouma, B. Troost, D. P. I. van de Pol, H. H. van der Ende-Metselaar, D. van Gosliga, L. Apperloo, O. A. Carpaij, M. van den Berge, M. C. Nawijn, Y. Stienstra, I. A. Rodenhuis-Zybert, J. Smit

This study compares the antiviral activity of moxidectin and ivermectin against SARS-CoV-2 in Vero E6 cells and human airway epithelial cells, finding inhibition in Vero cells but not in human cells.

bioRxiv · May 17, 2021Microbiology

Resveratrol And Pterostilbene Potently Inhibit SARS-CoV-2 Replication In Vitro

B. M. ter Ellen, N. Dinesh Kumar, E. M. Bouma, B. Troost, D. P. I. van de Pol, H. H. van der Ende-Metselaar, L. Apperloo, D. van Gosliga, M. van den Berge, M. C. Nawijn, P. H. J. van der Voort, J. Moser, I. A. Rodenhuis-Zybert, J. M. Smit

This study shows resveratrol and pterostilbene inhibit SARS-CoV-2 replication in vitro in multiple cell types, with long-lasting antiviral effects.

bioRxiv · Sep 24, 2020 · PreprintMicrobiology

Designing and implementing programmable depletion in sequencing libraries with DASHit

D. Dynerman, A. Lyden, J. Quan, S. Caldera, A. McGeever, B. Dimitrov, R. King, G. Cirola, M. Tan, R. Sit, M. van den Berge, H. A. M. Kerstjens, A. Faiz, S. Christenson, C. Langelier, , E. D. Crawford

The paper introduces DASHit, a software tool that designs CRISPR-based depletion targets to reduce high-abundance sequences in sequencing libraries, demonstrating its effectiveness across three species.

bioRxiv · Jan 12, 2020 · PreprintMicrobiology

A cellular census of healthy lung and asthmatic airway wall identifies novel cell states in health and disease

F. A. Vieira Braga, G. Kar, M. Berg, O. A. Carpaij, K. Polanski, L. M. Simon, S. Brouwer, T. Gomes, L. Hesse, J. Jiang, E. S. Fasouli, M. Efremova, R. Vento-Tormo, K. Affleck, S. Palit, , S. A. Teichmann

The paper uses single-cell transcriptomics to identify novel cell states in healthy and asthmatic lung tissues, revealing changes in cell communication and immune responses.

bioRxiv · Jan 23, 2019 · PreprintImmunology