R. R. Woldhuis

This study shows that SASP from senescent fibroblasts in severe early-onset COPD promotes paracrine senescence, inflammation, and ECM dysregulation in surrounding fibroblasts.

This study shows E-cigarette vapour induces cellular senescence in primary human lung fibroblasts, impairing tissue repair, but not in a mouse model.

This study identifies ECM gene and protein changes in COPD lung tissue linked to cellular senescence, confirming in vivo associations previously observed in vitro.