Ca2+/Calmodulin Dependent Protein Kinase Kinase-2 (CaMKK2) promotes Protein Kinase G (PKG)-dependent actin cytoskeletal assembly to increase tumor metastasis
D. Mukherjee, R. A. Previs, C. N. Haines, M. Al Abo, P. K. Juras, K. C. Strickland, B. Chakraborty, S. Artham, R. Whitaker, K. L. Hebert, J. Fontenot, S. R. Patierno, J. A. Freedman, F. H. Lau, M. Burow, , D. P. McDonnell
This study identifies CaMKK2 as a driver of tumor metastasis through a novel signaling pathway involving PDE1A, PKG1, and VASP, suggesting it as a therapeutic target for TNBC and HGSOC.
bioRxiv · Apr 17, 2023 · PreprintCancer Biology